Pumilio-2 Function in the Mouse Nervous System

Pumilio-2 Function in the Mouse Nervous System

Coordinated mRNA translation at the synapse is increasingly recognized as a critical mechanism for neuronal regulation. Pumilio, a translational regulator, is known to be involved in neuronal homeostasis and memory formation in Drosophila. Most recently, the mammalian Pumilio homolog Pumilio-2 (Pum2) has been found to play a role in the mammalian nervous system, in particular in regulating morp...

ADENOSINE IN THE CENTRAL NERVOUS SYSTEM

Besides being a metabolite of nucleotides like ATP, adenosine is a mediator of neuronal function in the central nervous system. Its actions are mediated by at least three extracellular receptors. In this review different aspects of adenosine such as biosynthesis, release, inactivation and its receptors are discussed. It also covers pre- and postsynaptic effects as well as postreceptor mecha...

Function and dysfunction in the nervous system.

Uridine function in the central nervous system.

In the adult nervous system, the major source of nucleotide synthesis is the salvage pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine is phosphorylated to nucleotides, which are used for DNA and RNA synthesis as well as for the synthesis of membrane constituents and glycosylation. Uridine nucleotides and UDP-sugars may be released from neuronal and gli...

Assessment of autonomic nervous system function in patients with non-alcoholic cirrhosis

Automatic dysfunction may contribute to the hemodynamic disturbances in cirrhosis. Tests of autonomic function were performed in 31 patients with non-alcoholic cirrhosis and 30 healthy subjects. Patients were divided into 3 groups according to child- Pugh,s classification ( A.B.C). The patients with moderate and severe cirrhosis( child B,C) had significant parasympathetic disturbance ( in the v...